How Much Semaglutide Per Week — and What Does It Actually Cost?

What NICE and the trial data tell us about the weekly dose schedule

NICE's appraisal of semaglutide for weight management (TA875) is built around a titration schedule that begins at 0.25 mg weekly and steps up through 0.5 mg, 1.0 mg and 1.7 mg before reaching the 2.4 mg maintenance dose, each step taken roughly four weeks apart, at the prescriber's discretion. That graduated approach is deliberate. The STEP 1 trial, published in the New England Journal of Medicine, showed around 15% average body weight reduction over 68 weeks at the 2.4 mg dose, the weekly amount the whole schedule is designed to reach safely. In January 2026 the MHRA also approved a 7.2 mg maintenance dose, later supplied via a dedicated single-dose pen approved in April 2026, for adults with a BMI of 30 or above. That higher ceiling brings the potential weekly dose for some patients to three times what was previously standard. What stays constant across every dose level is the clinical framework around it: a prescriber sets it, reviews it and adjusts it. No one dose is right by default.

How UK private pricing maps onto each weekly dose

Private Wegovy pricing is sold per pen, and each pen covers four weekly doses, so the monthly cost and the weekly dose are the same conversation. From September 2025, Eli Lilly revised the UK list price for Mounjaro (tirzepatide, the comparable alternative), with the highest-dose pen rising from around £122 to around £330; Wegovy pricing from private providers has tracked a similar range. As reported across the pharmacy sector, private semaglutide treatment typically costs somewhere between £149 and £375 per month depending on the dose and the service. The lower end of that range tends to correspond to the starter doses; the upper end to the higher maintenance doses. Worth knowing: the weekly dose you are on when you order determines the pen strength you need, which determines the price tier. If you are moving up the schedule, our page on the Wegovy 2.7 mg price explains what to expect at that particular step, useful if you are thinking ahead to payday or want to factor in a holiday. A full breakdown of what the monthly cost looks like by dose makes this easier to plan around.

What headline prices routinely leave out

A quoted price for semaglutide online can mean several different things. At its most stripped-back, it covers the medicine alone. More often the advertised number excludes the consultation fee (some providers charge £20–£50 or more), the prescription fee, delivery charges, or any clinical support between doses. Those extras add up quickly, and they are not trivial, a prescriber-reviewed consultation before every repeat supply is a legal requirement, not an optional service tier. At nume, sorry. At our pharmacy, one transparent price includes the consultation, the prescription, the medicine and tracked next-working-day delivery, with aftercare included. We are not the cheapest option available. That is a deliberate choice: speed, genuine clinical oversight and a fully regulated supply chain cost something, and we do not cut those corners to win a price comparison. More on what drives the total cost of semaglutide treatment, and how to read a price honestly.

Why the cheapest weekly dose is the wrong thing to optimise for

Semaglutide is a Prescription-Only Medicine. The MHRA has issued clear public guidance that GLP-1 medicines are not assessed for quick or cosmetic weight loss, and has warned repeatedly about fake pens sold without a prescription through social media and unverified online sellers. Large seizures of counterfeit weight-loss pens have been made across the UK, with some containing insulin rather than semaglutide. Choosing a provider because their quoted price is lowest is a reasonable instinct for most purchases. For a POM, it is the wrong test: the right questions are whether the pharmacy is registered on the GPhC register, whether a qualified prescriber reviews your case before every supply, and whether the medicine comes from the licensed UK supply chain. You can report any suspect seller or unexpected side effect at the MHRA's Yellow Card scheme. Start a free consultation with our prescribers if you want to understand which dose and treatment would suit your situation, the clinical picture always comes before the pricing one. For a broader look at results, this page covers how much weight loss per week you can realistically expect on Wegovy, based on the available evidence. This page covers what the evidence says about weekly weight loss on semaglutide.