The Mounjaro dosage chart: how the UK titration schedule actually works

Step 1, starting at 2.5 mg and understanding why the first pen is not the working dose

The KwikPen you receive at the beginning of treatment contains 2.5 mg tirzepatide per dose. Four doses per pen, one injection per week: so the first pen covers your first month. The job of that pen is not to drive significant weight loss, it is to let your digestive system settle in. Tirzepatide slows gastric emptying and acts on two gut-hormone receptors (GIP and GLP-1 simultaneously), which means starting at a higher dose from day one would overwhelm most people with nausea and other gastrointestinal effects.

After four weeks on 2.5 mg, your prescriber reviews how you are getting on. If you have tolerated it well, the next pen steps up to 5 mg. You can read more about what to expect from that transition on the Mounjaro 5 mg guide. The review before every step-up is not a formality, it is the point at which a real clinician looks at your response, not software. That is the clinical norm for this medicine.

Storage matters from the moment your pen arrives. Mounjaro is sent refrigerated; consult the Patient Information Leaflet for the permitted room-temperature window, because it changes by dose and circumstances. The pen itself is slim, pre-filled and colour-coded by strength, so distinguishing your current dose from the next one is straightforward once you know the system.

Step 2, the titration ladder from 5 mg to 15 mg and what the millilitre figures represent

Once tolerability is established at 2.5 mg, most people move through the remaining five strengths in roughly four-week steps, subject to prescriber review at each stage. Here is the full UK dosage chart, doses by strength, with the volume each pen delivers, because searches for the Mounjaro dosage chart in ml reflect a practical question people have when reading the pen's markings.

Each KwikPen contains a 3 ml cartridge at any strength. The concentration changes with each dose tier, so the volume you actually inject stays at a fixed 0.5 ml regardless of the strength, the pen's mechanism adjusts concentration, not the physical volume drawn. That is why the mounjaro dosage chart in ml looks the same at every rung: 0.5 ml per injection, every time. What differs is how many micrograms of tirzepatide are in that 0.5 ml. The pen handles that automatically; there is no dial, no measurement for you to perform.

The full ladder: 2.5 mg → 5 mg → 7.5 mg → 10 mg → 12.5 mg → 15 mg. Clinical trial data published in the SURMOUNT-1 paper in the New England Journal of Medicine showed average body-weight reductions of around 20–21% at 15 mg over 72 weeks in people with obesity, though individual results vary. Not everyone reaches 15 mg, some people find a lower dose both effective and comfortable, and staying at that dose is a legitimate clinical outcome. The full tirzepatide dosage chart covers all six strengths in more detail.

Step 3, what your prescriber considers before each dose increase

A dosage chart shows a schedule. What it cannot show is the clinical reasoning that governs whether you move along it. Before each step-up, your prescriber looks at how you are tolerating the current dose, specifically whether gastrointestinal side effects (nausea, changes in bowel habits, reduced appetite to a degree that is affecting nutrition) have settled, and whether you are managing injections consistently. If side effects are still prominent at week four, staying at the same dose for another four weeks is the appropriate call, not pushing ahead.

People sometimes ask whether they can skip a rung to speed things up. The answer is a clinical one, not a chart one, your prescriber decides based on your individual picture. Similarly, if you miss a dose, the guide to missed doses and their effects explains what the SmPC advises and when to seek guidance. Dose decisions, timing adjustments and any changes to your schedule belong to your prescribing team.

For context on what the titration journey tends to look like in terms of weight loss over time, the dosage chart for weight loss page maps the clinical evidence at each strength. And if you want to understand how units translate across different ways of reading the pen, the dosage chart in units breaks that down clearly.

Getting started: the private route through a registered prescriber

Mounjaro is available on the NHS in phased eligibility cohorts, with strict criteria around BMI and the number of qualifying health conditions you have, NICE's appraisal of tirzepatide (TA1026) sets those thresholds out. Many people do not meet the current NHS criteria or prefer not to wait, and a private prescription from a GPhC-registered online pharmacy is the legal alternative.

At nume, the process is straightforward. You complete a free online consultation, which is personally read by a GPhC-registered Independent Prescriber the same day. There is no algorithm making the approval decision, a named clinician does. If treatment is clinically appropriate, your prescription is issued and your first pen is dispatched the same day (for orders placed before 12 pm, Monday to Friday), arriving by DPD tracked delivery the next working day in plain, unbranded packaging. You can look at Mounjaro pricing to understand what that single transparent cost covers, and the Mounjaro overview sets out the full picture of the medicine before you decide. You can also verify our pharmacy on the GPhC register at pharmacyregulation.org using registration number 9012878.

The dosage chart is a useful map. The prescriber is the navigator. When you are ready to take the first step, start your free consultation.