Mounjaro How to Use: Video Walkthrough and Injection Guide

Each Mounjaro KwikPen contains four weekly doses — one pen lasts the whole month.
The three licensed injection sites are the abdomen, outer thigh, and upper arm; rotating between them reduces skin irritation.
Treatment begins at 2.5 mg, a tolerability dose designed to let your body adjust gradually before any increase.
Always check that the dose window shows the correct dose, and keep the pen refrigerated between 2–8 °C until needed, see the Patient Information Leaflet for the room-temperature window.

The Mounjaro KwikPen is a pre-filled, once-weekly injection — and most people find the technique straightforward once they've seen it done. This page walks you through each step clearly, explains what the pen is actually doing, and points you to the key things the Patient Information Leaflet flags as essential. Mounjaro (tirzepatide) is a prescription-only medicine, so your prescriber will have assessed whether it's right for you before you reach this stage. If you're still working out whether treatment is an option, our weight-loss treatment overview is a useful starting point.

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Step-by-step injection technique, what the pen is designed to do, and how to check it went in correctly

What does the Mounjaro video guide actually show you?

A short video is often the fastest way to demystify a self-injection. What good how-to-use Mounjaro pen video content covers is a consistent set of steps: gathering your supplies, choosing and preparing the site, attaching the needle, dialling the dose, injecting, and disposing safely. The pen itself is engineered to do most of the work. You press it against the skin, press the button, and the mechanism drives and retracts the needle automatically, you don't handle the needle directly at any point.

When your pen arrives (it comes in plain, unbranded packaging, tracked by DPD right to your door), take a moment before the first injection to read the leaflet in full. The visual walkthrough below mirrors that leaflet sequence, but the leaflet is the definitive reference, particularly for the room-temperature storage window and the signs that a pen should not be used.

The Mounjaro injection video guide on our site covers the visual steps in detail. It's worth bookmarking for your first two or three injections until the routine feels natural. Most patients tell us the anticipation is almost always worse than the act.

How do you prepare the pen and choose an injection site?

Start by checking the expiry date and looking at the liquid through the viewing window, it should be clear or very slightly yellow, with no particles. If anything looks off, do not use that pen; contact your prescriber or our aftercare team via the contact page.

Choose one of the three approved sites: the soft area around the navel (at least two inches away from it), the outer thigh, or the upper arm. Rotate your chosen site each week, using the same spot repeatedly can cause the skin to thicken, which affects absorption. Our injecting Mounjaro video page illustrates site rotation with simple diagrams.

Clean the area with an alcohol swab and let it dry fully, damp skin stings more. Attach a new needle per the pen's instructions. Never reuse a needle between injections; our needles (100-pack) are available if you need replacements. If you want a closer look at exactly how the needle attaches and the button press works, our how to inject Mounjaro video walks through each step clearly before you begin. Hold the pen firmly against the skin at a 90-degree angle, press the button, and hold steady until the dose counter returns to zero. That zero is your confirmation the full dose was delivered.

Unsure whether everything went to plan? The how to know if you injected correctly page answers the most common checks people run through afterwards.

What happens if a small drop appears or the site bleeds?

A tiny droplet at the injection site is normal and does not mean the dose was lost, the volume injected is very small. A dot of blood at the site is also common; press gently with a clean tissue for a few seconds. Neither of these is a reason to inject again. Re-injecting a dose you've already taken is a frequently asked question our prescribers field regularly, the answer is always: do not repeat the dose, and speak to your prescriber if you're unsure what happened.

After injecting, cap the pen (do not recap the needle, remove it first), and return it to the fridge. Dispose of used needles in a sharps container; a 1-litre sharps bin is available from our pharmacy and is the safe, compliant option at home.

For a more detailed visual guide to the pen, the how to inject Mounjaro with the pen video page steps through needle attachment and removal frame by frame. The NHS tirzepatide patient information page is also a reliable plain-English reference for common injection questions.

What side effects should you know about before your first injection?

Most people experience some gastrointestinal effects when starting or moving to a higher dose, nausea is the most common, followed by loose stools, constipation, indigestion, and burping. These tend to be most noticeable in the day or two after an injection and often settle within a couple of weeks. Eating smaller portions, avoiding rich or fatty food around injection day, and staying well hydrated all help.

A few symptoms warrant prompt medical attention: severe or persistent stomach pain, especially if it radiates toward your back, can be a sign of pancreatitis, seek same-day medical review. The MHRA highlighted this risk in a Drug Safety Update in January 2026. Similarly, signs of an allergic reaction (rash, difficulty breathing, swelling of the face or throat) require urgent care.

You can report any suspected side effects directly to the MHRA at the Yellow Card scheme. Our prescribers are also available seven days a week for aftercare questions, you do not need to wait for a routine appointment. For a full picture of what tirzepatide is and how it works, the Mounjaro overview page covers the science clearly. If you're yet to start treatment and want to understand what's involved, checking your eligibility is a good first step.

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The people

Meet the team.

Mahommed Zunaid Ayub Patel

Superintendent Pharmacist (GPhC No. 2217101)

Accountable for the safe running of our registered pharmacy, from every dispensing check to every dispatch.

Mostafa Damghani

Clinical Lead (GPhC No. 2231744)

Sets our clinical standards and checks everything we publish against current MHRA guidance.

Shelan Salih

Independent Prescriber (GPhC No. 2084501)

Personally reviews consultations and assesses whether treatment is clinically appropriate, and leads dose adjustments and follow-up checks.

Rehenaaz Uddin

Independent Prescriber (GPhC No. 2083426)

Personally reviews consultations and assesses whether treatment is clinically appropriate, and leads dose adjustments and follow-up checks.

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