Mounjaro instructions video: what to watch before your first injection

Mounjaro's KwikPen contains four weekly doses; each injection uses a fresh needle applied to the pen just before use.
Injection sites are the abdomen, outer thigh, or upper arm; rotating the site each week helps reduce local skin reactions.
The pen should be stored in the fridge at 2–8°C; check the Patient Information Leaflet for the precise room-temperature window if you need to carry it with you.
The official Eli Lilly video and the printed instructions inside the box cover the same steps; watching the video and reading the leaflet together is the approach most patients find clearest.

Your pen has arrived in a plain, unbranded box via DPD, and you've got a text with the tracking link. Now comes the part that makes most people hesitate: picking up the pen and actually doing it. Mounjaro is administered as a once-weekly subcutaneous injection using a pre-filled KwikPen, and Eli Lilly publishes official step-by-step video guidance to walk you through every stage before you begin. These are prescription-only medicines, so once a prescriber has confirmed suitability, a video walkthrough and the Patient Information Leaflet work together to make the technique as straightforward as possible.

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How to follow the Mounjaro KwikPen video guide from your first dose to steady routine

The moment you open the box: what you're looking at and why the video helps

You lift the lid and there it is: a small auto-injector pen, needles in a separate pouch, and a folded leaflet. The KwikPen looks compact, but first-timers often find the sequence of steps easier to absorb from a video than from diagrams alone. Eli Lilly UK publishes official how-to footage specifically for Mounjaro; your prescriber or the Patient Information Leaflet will point you to it, and it covers everything from checking the pen's expiry date to confirming the dose window is clear.

Before you press play, take a moment to gather what you need: the pen itself, a clean needle from the pack, an alcohol swab to clean the skin, and a sharps container for disposal. The full written injection guide sets out these preparation steps in detail if you want to read alongside the video. Both formats cover the same clinical sequence; neither replaces the other.

One thing the video makes genuinely clearer than a diagram: how long to hold the pen in place after the injection button is pressed. Removing it too quickly is the most common first-timer error. The footage shows the indicator window turning, confirming the dose is delivered. That visual cue alone is worth the two minutes of running time.

What the video actually shows, step by step

Official Mounjaro instruction videos follow a consistent sequence. They open with storage and inspection: checking the liquid in the dose window is clear, colourless and free of particles, and confirming you are on the correct dose. If you are unsure about titration timing or which strength your prescriber has authorised, the tirzepatide administration instructions page covers that in plain language, though all titration decisions sit with your prescriber.

The video then walks through needle attachment, skin preparation, site selection, and the injection itself. For site selection, the abdomen, outer thigh and upper arm are all shown, with a note on why rotation matters: repeated use of the same small area can cause changes to the fatty tissue beneath the skin that affect absorption. The Mounjaro jab video page pulls together additional visual resources if you want more than one demonstration before you feel ready.

Post-injection steps matter too. The needle is removed and capped immediately; it goes directly into your sharps container, not the household bin. Pressing gently on the injection site for a few seconds without rubbing is shown as standard technique. The NHS tirzepatide medicine page sets out practical guidance on using Mounjaro, including what to do if a dose is missed, in clear patient-level language.

Questions the video cannot answer — and who to ask instead

A video guide covers technique. It cannot tell you whether a particular injection site feels unusually firm this week, whether a small lump under the skin is worth mentioning to your prescriber, or whether the mild nausea you felt after the first dose is typical. Those are exactly the questions a clinical team handles.

Common side effects reported in the SURMOUNT programme (nausea, constipation, mild reflux and fatigue) tend to settle as the body adjusts, particularly in the early weeks. They are more noticeable after starting or after a dose step. If you experience severe, persistent stomach pain that radiates to the back, that warrants prompt medical attention, as the MHRA has highlighted acute pancreatitis as an infrequent but serious consideration with GLP-1 medicines.

For broader background on what tirzepatide is and how it works, the tirzepatide overview and the Mounjaro information page fill in the clinical picture. If you are at the stage of comparing treatment costs, the Mounjaro prices guide explains how UK private treatment is structured. And if you have a question that sits outside technique (something about eligibility, a health condition, a medicine you already take) the FAQs are a good starting point, or you can contact our team directly.

When you feel ready to take the first step with clinical support behind you, you can speak to our prescribers through a free consultation, reviewed the same day by a GPhC-registered Independent Prescriber.

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