How much weight do people lose on Mounjaro?

What the clinical evidence actually shows about weight loss on Mounjaro

The SURMOUNT-1 figures are worth sitting with for a moment. At 15mg, participants lost around 20–21% of body weight on average over 72 weeks, that is roughly 22–23 kg for someone starting at 110 kg. At 10mg the average was around 19%, and at 5mg approximately 15%. These are averages across thousands of participants; some people lose more, some less. The results hold up in a head-to-head comparison too: NICE's appraisal of tirzepatide (TA1026) reviewed the SURMOUNT programme alongside indirect comparisons, concluding that tirzepatide produced greater average weight reduction than semaglutide 2.4mg, a finding confirmed directly in the SURMOUNT-5 trial published in 2025.

A few things shape where on that range you land. The dose you ultimately tolerate matters most, not everyone gets to 15mg, and titration happens gradually over months. Duration counts too; most of the weight loss in SURMOUNT-1 was still accumulating at week 36. Lifestyle factors (protein intake, activity, sleep) affect outcomes in a way that the prescriber and any supporting dietitian can help you think through. Our personalised weight-loss on Mounjaro page explores these individual variables in more depth.

One thing that is easy to miss: the 2.5mg starting dose exists to help your system adjust, not to produce significant weight loss itself. The therapeutic work starts as the dose builds. If you are curious about how much weight you can lose on Mounjaro 5mg, our dedicated guide covers what to expect at that stage in detail.

What private Mounjaro pricing covers, and what it sometimes doesn't

UK private weight-loss treatment is priced per pen or per month, and it varies between providers both by dose and by what is bundled into the headline figure. Since Eli Lilly raised Mounjaro's UK list price in September 2025, the highest-dose pen's list price rose to around £330; typical private prices across providers range roughly £149–£375 per month depending on the dose, figures widely reported at the time of the price change. These numbers shift, and any comparison you find online may already be out of date.

What matters as much as the headline figure is what it actually includes. Some providers charge separately for the consultation, the prescription, delivery or ongoing clinical support. If those costs are listed individually (or not listed at all) the real monthly outlay can be higher than the pen price suggests. Our Mounjaro pricing page walks through what goes into a legitimate private price and how to compare providers fairly.

You may have noticed that many of those wanting to understand how much weight you can lose on Mounjaro are also working out whether the cost is worth it. That is a completely reasonable question. The honest answer is that, for a medicine producing average losses of 20% body weight in trials, the clinical value is meaningful, but only when treatment is genuine, supervised and consistent.

What nume charges, and why we are not the cheapest option

We lose the price comparison on purpose. One price at nume covers your free clinical consultation, your prescription, the treatment itself, free next-working-day tracked DPD delivery and access to our prescribing team seven days a week for aftercare. Nothing is added at checkout; nothing is billed monthly without your choosing to continue.

Explore our weight-loss treatment options to see current pricing. There are no discount codes, no promotional periods and no subscription that bills you automatically. Every repeat order goes back in front of a prescriber before anything is dispatched. That structure costs more to run than a pure dispensing model, and that cost is reflected in the price. If you want to understand how our clinical team approaches treatment decisions, our clinical lead's profile sets out the standards we hold ourselves to.

For context on the broader range of weight-loss treatment available in the UK, including how Mounjaro compares to other licensed options, our treatment overview is a practical place to start.

Why 'cheapest' is the wrong question to ask for a prescription medicine

Mounjaro is a Prescription-Only Medicine. Legally, it can only be supplied following a clinical assessment by a prescriber, and that assessment should be real, not a formality. The MHRA has warned publicly about fake tirzepatide pens circulating online, including a 2025 raid on an illicit UK manufacturing site producing counterfeit pens. Approximately 20 million doses of illegally traded weight-loss medicines (worth an estimated £45m) were seized in enforcement operations that year.

Low prices from unverified sellers, offers that appear without a clinical assessment, and anyone offering these medicines without a valid prescription are all red flags. A small saving on a counterfeit pen is not a saving at all. The MHRA's Yellow Card scheme accepts reports of suspected fake or substandard medicines, and any online pharmacy you use should be verifiable on the GPhC register, nume's registration number is 9012878.

For more detail on realistic weight-loss outcomes across the full dose schedule, and a breakdown of what drives results beyond the headline trial figures, those pages sit alongside this one.