How much weight do you lose per week on Wegovy?

Step 1: the first four weeks — why loss is slower than you might expect

The first Wegovy pen contains a 0.25 mg dose. That starting strength exists specifically to give your body time to adjust to semaglutide; the gastrointestinal system in particular needs that settling-in period before the dose climbs. Weight loss in these early weeks is often modest, sometimes a kilogram or two, sometimes less. That is entirely normal, and it does not tell you much about how your body will respond at the higher maintenance doses.

A question our prescribers hear regularly is whether slow early progress means the medicine is not working. It almost never does. The 0.25 mg starting level is a tolerability measure, not a therapeutic target. Your actual response to treatment becomes clearer once the dose increases begin, typically from week five onwards under prescriber guidance.

If you are curious about what the first week specifically looks like for most people, the picture there is almost always very gentle movement, which is the right way to start.

Step 2: the dose-increase phase, where most measurable weekly loss happens

As semaglutide is titrated upwards through 0.5 mg, 1.0 mg and 1.7 mg to the 2.4 mg maintenance dose, appetite suppression and gastric slowing become progressively more pronounced. This is the phase where many people start to notice consistent weekly losses, and if you want to understand how much weight loss per week on Wegovy is typical during this period, the figures vary meaningfully depending on dose stage and individual factors. Body composition, starting weight, dietary changes and activity level all play a role.

The STEP 1 trial, cited above, ran for 68 weeks with participants at the 2.4 mg dose; the average total loss of around 15% translates to roughly 0.5–0.7 kg per week across the full programme when spread evenly, though in practice the earlier weeks are slower and the middle of the programme sees faster movement. The NHS medicines page for semaglutide gives a clear patient-level overview of how the medicine works and what to discuss with your prescriber.

For a closer look at monthly averages across the programme, those figures give a more practical sense of progress than week-by-week snapshots, since weight loss is rarely perfectly linear.

Step 3: maintenance, rate naturally slows, and that is a sign the treatment is working

Around the time patients reach and settle on the 2.4 mg dose, weekly loss typically slows as the body adjusts to a lower intake and a new weight equilibrium approaches. This is not a plateau caused by the medicine failing, it is physiology behaving as expected. Most people in the STEP 1 trial had reached close to their maximum weight reduction by week 60–68, with smaller week-on-week changes in the later months. Reading about how much weight you can lose a week on Wegovy across the full treatment arc helps set realistic expectations for both the faster middle phase and the slower later months.

A newer higher dose, 7.2 mg, was approved by the MHRA in April 2026 for adults with a BMI of 30 or above; early data suggests average losses of around 20.7% over 72 weeks at that dose. Whether a specific dose or pen format is right for you is confirmed at your clinical consultation, not before it.

The expected weekly rate at each stage of treatment is worth reading alongside this page, since it sets realistic benchmarks rather than best-case projections.

The cost context: what Wegovy actually costs per week, and why price is the wrong starting point

Private Wegovy treatment in the UK is priced per pen (each pen covers four weekly doses). Since Eli Lilly's widely reported price adjustments in late 2025, private market prices for semaglutide have ranged roughly £149–£375 per four-week pen depending on dose and provider, so somewhere between £37 and £94 per week in broad terms, though these are market estimates and change. What the headline figure on any provider's site may not show: consultation fees, prescription charges, delivery costs, and whether there is any clinical support if something changes mid-treatment.

At nume, one price covers the consultation, the prescription, the medicine, free next-working-day delivery, and 7-day aftercare. We are not the cheapest option available, that is a deliberate choice, not an oversight. A lower headline number that excludes clinical oversight or aftercare is not a better deal; it is a different product.

For a full breakdown, the Wegovy price page sets out what private treatment costs in the UK and what to look for when comparing providers. You can also visit our Wegovy treatment cost page for the full picture of what is included at nume. The consultation page is where treatment starts, no referral, no waiting list, subject to your prescriber confirming suitability.

For a prescription medicine, price per week is genuinely the wrong measure to lead with. Clinical legitimacy, verified supply chain, and ongoing prescriber oversight are what keep treatment safe. The GPhC register at registration number 9012878 confirms nume as a regulated pharmacy, worth checking for any online provider you consider.