How much weight loss on Wegovy, and what does it actually cost?

What the trial results actually show — and what they don't

The 15% average from STEP 1 is the number most cited, and it's a useful anchor. But averages obscure a wide spread. Some participants in that trial lost closer to 5%; others lost more than 20%. If you want a clearer sense of the realistic range, our guide to how much weight you can lose on Wegovy works through what the data actually shows across different groups. Weight loss on Wegovy depends on your starting point, how carefully you adjust your diet and activity, how well you tolerate the medicine as the dose increases, and how long you stay on treatment.

The NHS medicines page for semaglutide notes that the most common side effects are gastrointestinal (nausea, loose stools, constipation, indigestion) and these are most noticeable in the early weeks or after a dose step. Pushing through that period with adequate food and fluid, rather than stopping early, matters for outcomes. A prescriber who checks in before each repeat isn't just a regulatory formality; it's the mechanism that keeps you on track.

If the question is specifically about week-by-week progress, our breakdown of weekly Wegovy results goes into more detail on what to expect at each stage of the titration schedule. For those wondering what to expect specifically while on the starting dose, our page on weight loss at 0.25 mg explains what's typical in those early weeks before the titration steps up.

What UK private Wegovy pricing typically includes, and what it often leaves out

Private Wegovy pricing in the UK varies between providers and shifts with each dose step, because each pen supplies four weeks of treatment. Any legitimate price you see should already cover the prescription itself; the medicine is a Prescription-Only Medicine, so a clinical assessment and prescriber sign-off are required by law before it can be dispensed. In practice, some headline prices cover only the pen. Consultation fees, prescription charges, delivery costs and any aftercare or dose-review support may appear as separate line items, or not appear in the breakdown at all until checkout.

Worth knowing if you plan around payday or order ahead of a holiday: at nume, there are no subscription auto-renewals. Every repeat is a fresh clinical review. You order when you're ready, and if you order before 12pm on a working day, dispatch goes out the same day. Understanding what Wegovy weight loss actually costs across the full course of treatment is worth doing before you commit, since the per-pen price is only part of the picture. For a fuller look at how UK private pricing is structured across dose levels, our Wegovy price guide sets out the landscape honestly.

The Lilly price-change in Mounjaro made headlines in late 2025; semaglutide pricing has had its own movements too. How Wegovy's UK price has shifted is worth reading if you're comparing historical quotes with current ones.

Where nume sits, and why we're not trying to be cheapest

Cheapest isn't a race we entered. One transparent price at nume covers the consultation, the prescription, the medicine, free next-working-day tracked delivery and seven-day aftercare, nothing added at checkout. There's no subscription and no auto-renewal. A real clinician, not software, reads your consultation answers; the same prescriber standard applies to every repeat and every dose step.

That structure costs more than a bare-pen listing from a seller with a fast checkout and no visible aftercare. For a prescription medicine where the clinical support around the pen is a significant part of whether it works and whether you stay safe, that gap matters more than the headline saving. You can see current treatment pricing on our treatment page, and read about how nume is set up on our about page. If you want to verify our GPhC-registered pharmacy, the GPhC register entry for premises number 9012878 is public.

When 'cheapest' is the wrong question for a prescription medicine

Price is a reasonable thing to compare. But for a Prescription-Only Medicine dispensed by injection, the question isn't only what the pen costs, it's what comes with it. The MHRA has warned publicly about counterfeit weight-loss pens sold online, including fake pens that have contained insulin rather than the labelled medicine. Sellers offering these medicines without a clinical assessment or from unverified sources are a real and documented risk, not a theoretical one.

The safe route is a pharmacy you can verify on the GPhC register, dispensing from the licensed UK supply chain, with a real prescriber making the clinical call. Suspect sellers can be reported via the MHRA's Yellow Card scheme. If a listing seems unusually cheap or offers to supply Wegovy with no assessment involved, that's the signal to look more carefully, not less. Our guide to Wegovy pharmacy costs covers what legitimate pricing looks like and why the spread exists. For a broader look at the treatment, our Wegovy overview is a good starting point before your consultation.