How much weight will I lose on semaglutide — and what shapes the answer?

What does the clinical evidence say about how much weight you can lose on semaglutide?

The STEP 1 trial (published in the New England Journal of Medicine) followed 1,961 adults with obesity over 68 weeks. Participants taking semaglutide 2.4mg lost around 15% of their body weight on average, compared with roughly 2.4% in the placebo group. For a person starting at 110 kg, that translates to approximately 16–17 kg. A meaningful portion of participants lost more than 20%.

The oral form, Wegovy tablets, shows a different picture. In the OASIS 4 trial, participants who stayed fully adherent to the 25mg maintenance tablet lost an average of around 17% over 64 weeks, but the overall trial average, including those who did not complete the full schedule, was closer to 13.6%. Both figures are cited by the MHRA in its approval of the tablet, and both are real; the gap between them reflects how much consistency matters. If you want to understand how much weight you'll lose on Wegovy across injection and tablet forms, that page sets out the comparison in full.

One practical check worth doing in under a minute: enter your current weight and the 15% trial average into a calculator. If you are curious about how much weight you can lose on semaglutide across different starting points and doses, that page walks through the numbers in detail. The number you see is a realistic trial-average outcome, not a guarantee, but a grounded reference point rather than a headline claim.

NICE's appraisal of semaglutide for weight management (TA875) notes that people who have not lost at least 5% of their body weight after six months at the maintenance dose should have their treatment reviewed, which is a useful benchmark during treatment too.

Does what you pay for semaglutide affect how much weight you lose?

The honest answer is: not directly. The medicine is the same molecule regardless of which regulated UK pharmacy dispenses it. What the price you pay can affect is how safely and consistently you stay on treatment, and consistency is precisely what drives results.

UK private prices for Wegovy have moved significantly since Novo Nordisk adjusted list pricing. Across providers, monthly costs typically run from around £149 at lower doses to over £300 at higher maintenance doses, depending on the pharmacy and what is bundled in. You can find a full breakdown on our Wegovy price page. These are the only per-provider £ figures it is sensible to share here, because a headline number stripped of what it includes is almost meaningless.

What headline prices often leave out: the initial consultation fee, a separate prescription charge, delivery costs per order, and any follow-up clinical review when you need a dose change. Those costs can add up to significantly more than a low headline suggests. If you want to understand how much weight you will lose on 1mg of Wegovy, that page covers what to expect at that specific dose before you commit to a full course. A full picture of cheaper alternatives to Wegovy (including what to watch for) is covered separately if you are weighing your options.

At nume, one transparent price covers the consultation, prescription, treatment, and free next-working-day delivery by DPD. We are not positioned as the cheapest option on the market, and that is deliberate. What it buys is a service with no billing surprises and clinical oversight at every stage.

Why 'cheapest' is the wrong question when choosing where to get semaglutide

Semaglutide is a prescription-only medicine. Under UK law, it requires a valid prescription following a genuine clinical assessment, there is no legal route to it without one. The MHRA has warned publicly and repeatedly about fake weight-loss pens sold online, some of which have contained insulin rather than semaglutide. Counterfeit products will not produce the weight loss described in clinical trials. They carry serious risk.

Before using any online pharmacy for a prescription medicine, spend thirty seconds checking it on the GPhC pharmacy register. A legitimate registered pharmacy will have a premises registration number you can verify directly. Sellers offering these medicines at prices far below the market rate, or appearing to supply them without a prescription or clinical check, are a red flag worth taking seriously. The MHRA's Yellow Card scheme at yellowcard.mhra.gov.uk is where you can report a suspect seller.

For a prescription medicine, the question that actually protects you is not 'where is this cheapest?' but 'where will I get genuine medicine, a real clinical review, and support if something goes wrong?' That is what regulated supply through a GPhC-registered pharmacy is designed to answer. You can explore our full treatment options or read more about how much weight you can realistically lose with semaglutide before deciding anything.