Is 1mg Wegovy the Same as 10mg Mounjaro?

Why does comparing 1mg Wegovy to 10mg Mounjaro by number not work?

The numbers on a pen label tell you the mass of the active ingredient in a single dose — nothing more. Semaglutide and tirzepatide are structurally unrelated molecules that work through different biological pathways. Wegovy (semaglutide) is a GLP-1 receptor agonist; Mounjaro (tirzepatide) acts on both the GIP and GLP-1 receptors simultaneously, making it the only dual-agonist weight-loss medicine licensed in the UK. Because the molecules are different, their doses cannot be converted into one another the way, say, two paracetamol brands can be compared.

Think of it like comparing 1mg of one antibiotic to 10mg of a completely different antibiotic. The ratio is meaningless without knowing the potency, half-life and mechanism of each drug. For Wegovy and Mounjaro, those things differ substantially. This question comes up often, understandably, because both medicines are titrated in milligrams and patients moving between them want a sensible reference point. Our page on switching between Mounjaro and Wegovy covers the conversion question in more practical detail.

In short: 1mg Wegovy is a mid-titration step on the semaglutide schedule; 10mg Mounjaro is a near-maintenance step on tirzepatide's. Neither is the other's equivalent, and treating them as such could lead to dose-related side effects or under-treatment.

Where do 1mg Wegovy and 10mg Mounjaro each sit in their own titration schedules?

Wegovy's titration path runs 0.25mg, 0.5mg, 1.0mg, 1.7mg and 2.4mg, each step held for around four weeks before the prescriber considers moving up. The 1mg step is therefore the third rung, still on the way to the standard 2.4mg maintenance dose, and if you are wondering whether 1mg Wegovy is the same as 7.5mg Mounjaro, that page works through the comparison in full. Most clinical trial evidence, including the STEP 1 study published in the New England Journal of Medicine, was built around 2.4mg as the target dose, which is where the headline result of around 15% average weight loss was observed over 68 weeks.

Mounjaro's schedule starts at 2.5mg and moves through 5mg, 7.5mg, 10mg, 12.5mg and 15mg, again in roughly four-week steps. The 10mg dose is therefore the fourth of six steps, approaching but not yet at the maximum. In SURMOUNT-1, tirzepatide at 15mg produced an average weight reduction of around 20–21% over 72 weeks in adults with obesity, as reported in the NEJM trial paper. Results at lower doses in the same trial were meaningful but more modest.

For a broader look at how lower doses compare across both medicines, the 0.5mg Wegovy vs 5mg Mounjaro comparison follows the same logic at an earlier point in titration. The shared thread across all these comparisons: the milligram numbers do not travel between the two drugs.

How do the two medicines compare on outcomes and tolerability?

The most direct head-to-head evidence comes from the SURMOUNT-5 trial, published in the New England Journal of Medicine in 2025. Over 72 weeks in adults with obesity but without diabetes, tirzepatide produced greater average weight loss than semaglutide 2.4mg. That does not make Mounjaro the automatic choice. Side-effect profiles are broadly similar, both medicines produce mainly gastrointestinal effects (nausea, loose stools, indigestion, reduced appetite) that tend to be most noticeable at the start of each new dose step before settling. Individual tolerance varies considerably.

The table below sets out the key factual differences between these two medicines at the specific doses in the keyword (1mg Wegovy and 10mg Mounjaro) and in their wider context.

NICE has appraised both medicines for NHS use: tirzepatide under TA1026 and semaglutide under TA875. The criteria differ, and for most people accessing either privately, NICE's NHS thresholds are a background reference rather than a gate.

A quick thing worth doing: check any online pharmacy you are considering on the GPhC register before handing over payment details. It takes under a minute and is the single most reliable way to confirm a pharmacy is legitimate. Counterfeit pens have been seized in large quantities in the UK, and they are more likely to come from unverified sellers than from GPhC-registered pharmacies.

Which medicine is right for you, and who decides?

The question of whether Mounjaro or Wegovy suits you better is not resolved by a dose comparison table. It depends on your medical history, any medicines you already take (contraception interactions differ between the two, worth discussing with your prescriber, as our Wegovy vs Mounjaro overview covers), your history with nausea, and whether cost is a practical factor. Our Mounjaro and Wegovy price comparison sets out what to expect on that side of the decision, and if you are also curious about whether Wegovy 2.4mg is the same as Mounjaro 2.5mg, that page addresses the comparison at the opposite ends of each titration schedule.

At nume, a named prescriber reviews your consultation the same day. They consider the full picture, not just the milligram number that caught your eye. Which treatment suits you is a clinical decision our prescribers make with you.

Ready to get a proper answer for your situation? Speak to our prescribers through a free consultation and find out which medicine, if either, is right for you.